Angiotensin II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion

Giora Feuerstein*, Michael Krausz, Silvia Cohen, Yehuda Gutman, Mahesh C. Khosla, Merlin F. Bumpus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Isoprenaline infusion into the renal artery of the cat induced an increase in the catecholamine (CA) secretion rate from the adrenal gland. CA release by isoprenaline was preferentially noradrenaline. Intravenous infusion of an angiotensin II (A II) antagonist abolished adrenal CA response to intrarenal isoprenaline injection. It is suggested that intrarenal isoprenaline infusion stimulates renal renin release and A II production which, in turn, stimulates adrenal CA secretion.

Original languageEnglish
Pages (from-to)375-377
Number of pages3
JournalEuropean Journal of Pharmacology
Volume52
Issue number3-4
DOIs
StatePublished - 1 Dec 1978

Keywords

  • Adrenal medulla
  • Angiotensin II
  • Catecholamines
  • Isoprenaline

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