Angiotensin increases microsomal (Na⁺-K⁺-ATPase activity in several tissues

Angiotensin increased microsomal (Na⁺K⁺)-activated ATPase from rat hypothalamus, mucosa of colon and bovine adrenal cortex but not brain cortex. Angiotensin did not change significantly Mg²⁺-ATPase in these tissues. Enhancement by angiotensin was evident at concentrations of 10^-8 - 10^-12 M. In bovine adrenal cortex angiotensin increased ATPase activity in the outer and not in the inner layer. Angiotensin increased ATPase activity with Na⁺ above 20 mM and K⁺ above 5 mM present simultaneously, but not with either ion alone.