Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma

Elad Horwitz; Ilan Stein; Yinon Ben-Neriah; Eli Pikarsky

doi:10.4161/23723548.2014.968028

Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma

Elad Horwitz, Ilan Stein, Yinon Ben-Neriah, Eli Pikarsky^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In contrast to common genomic amplifications that support cancer cell growth by rewiring intracellular signaling, VEGFA amplification drives tumor cell proliferation via the tumor microenvironment. VEGFA amplification is present in a subset of mouse and human hepatocellular carcinomas (HCCs) that appear to be particularly sensitive to sorafenib treatment, indicating its potential value as a biomarker for HCC treatment.

Original language	English
Article number	e968028
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/23723548.2014.968028
State	Published - 2 Jan 2015

Bibliographical note

Funding Information:
Research leading to these results received funding from the European Research Council Grant Agreements 281738 to E.P. and 294390 to Y.B-N.; the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF); the DKFZ-MOST cooperation; and the Israel Science Foundation (ISF) Centers of Excellence (1779/11).

Publisher Copyright:
© 2015, Published with license by Taylor & Francis Group, LLC.

Keywords

HCC
VEGFA
copy number variation
genomic amplification
macrophages
mouse model
sorafenib

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723548.2014.968028

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abstract = "In contrast to common genomic amplifications that support cancer cell growth by rewiring intracellular signaling, VEGFA amplification drives tumor cell proliferation via the tumor microenvironment. VEGFA amplification is present in a subset of mouse and human hepatocellular carcinomas (HCCs) that appear to be particularly sensitive to sorafenib treatment, indicating its potential value as a biomarker for HCC treatment.",

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Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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