Animal models of psychiatric disease

Jonathan Flint*, Sagiv Shifman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Animal models of psychiatric diseases are useful tools for screening new drugs and for investigating the mechanisms of those disorders. Despite the difficulties inherent in modelling human psychiatric phenotypes in animals, there has been recent success identifying mutations in mice that give rise to some of the characteristic features of anxiety, depression, schizophrenia, autism, obsessive-compulsive disorder and bipolar disorder. In some cases these models have the additional strength that drugs used to treat the human condition alleviate the symptoms in mice. Robust genetic evidence of the involvement of multiple susceptibility genes in psychiatric disease will enable future studies to move from single-gene models to models with multiple modified loci, with the promise of better representing the complexity of the human diseases.

Original languageAmerican English
Pages (from-to)235-240
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume18
Issue number3
DOIs
StatePublished - Jun 2008

Bibliographical note

Funding Information:
Jonathan Flint is funded by the Wellcome Trust.

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