Anion binding to nucleic acid bases. A quantum-mechanical exploration using electrostatic molecular potentials

B. Pullman*, A. Goldblum, H. Berthod

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Electrostatic molecular potentials are used to evaluate the binding abilities of monovalent simple anions to the nucleic acid bases. When the NH bond involved in nucleoside formation is disregarded the relative affinities of the bases towards Cl- are in the order guanine > cytosine > adenine > thymine = uracil. In guanine in particular a localized site of binding is found in the region between N1H and the NH2 group. These findings correlate satisfactorily with the scarce experimental data available.

Original languageAmerican English
Pages (from-to)1166-1169
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume77
Issue number4
DOIs
StatePublished - 22 Aug 1977
Externally publishedYes

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