Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials

Livnat Atar-Froyman; Anat Sharon; Ervin I. Weiss; Yael Houri-Haddad; Dana Kesler-Shvero; Abraham J. Domb; Raphael Pilo; Nurit Beyth

doi:10.1016/j.biomaterials.2014.12.047

Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials

Livnat Atar-Froyman, Anat Sharon, Ervin I. Weiss, Yael Houri-Haddad, Dana Kesler-Shvero, Abraham J. Domb, Raphael Pilo, Nurit Beyth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties invitro and invivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to invivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	Biomaterials
Volume	46
DOIs	https://doi.org/10.1016/j.biomaterials.2014.12.047
State	Published - 1 Apr 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

Keywords

Antibacterial
Maxillectomy
Nanoparticles
Polyethylenimine
Post-surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2014.12.047

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title = "Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials",

abstract = "Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties invitro and invivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to invivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.",

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doi = "10.1016/j.biomaterials.2014.12.047",

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AU - Sharon, Anat

AU - Weiss, Ervin I.

AU - Houri-Haddad, Yael

AU - Kesler-Shvero, Dana

AU - Domb, Abraham J.

AU - Pilo, Raphael

AU - Beyth, Nurit

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties invitro and invivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to invivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.

AB - Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties invitro and invivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to invivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.

KW - Antibacterial

KW - Maxillectomy

KW - Nanoparticles

KW - Polyethylenimine

KW - Post-surgery

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JO - Biomaterials

JF - Biomaterials

ER -

Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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