Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials

Livnat Atar-Froyman, Anat Sharon, Ervin I. Weiss, Yael Houri-Haddad, Dana Kesler-Shvero, Abraham J. Domb, Raphael Pilo, Nurit Beyth*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    46 Scopus citations

    Abstract

    Polycationic nanoparticles show biocompatible, broad-spectrum bactericidal properties invitro and invivo when incorporated in denture lining material post-maxillectomy in head and neck cancer patients. In the present study, the synthesized Crosslinked quaternary ammonium polyethylenimine nanoparticles were found to have a strong bactericidal activity against a wide variety of microorganisms rapidly killing bacterial cells when incorporated at small concentrations into soft lining materials without compromising mechanical and biocompatibility properties. This appears advantageous over conventional released antimicrobials with regard to invivo efficacy and safety, and may provide a convenient platform for the development of non-released antimicrobials. This is a crucial issue when it comes to giving an answer to the serious and life-threatening problems of contaminations in immunocompromised patients such as orofacial cancer patient.

    Original languageAmerican English
    Pages (from-to)141-148
    Number of pages8
    JournalBiomaterials
    Volume46
    DOIs
    StatePublished - 1 Apr 2015

    Bibliographical note

    Publisher Copyright:
    © 2014 Elsevier Ltd.

    Keywords

    • Antibacterial
    • Maxillectomy
    • Nanoparticles
    • Polyethylenimine
    • Post-surgery

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