Anti-proliferative activity of the combination of salan Ti(IV) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: Synergism with cisplatin

Nitzan Ganot; Boris Redko; Gary Gellerman; Edit Y. Tshuva

doi:10.1039/c4ra13484b

Anti-proliferative activity of the combination of salan Ti(IV) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: Synergism with cisplatin

Nitzan Ganot, Boris Redko, Gary Gellerman, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Two diaminobis(phenolato) Ti(iv) complexes were separately combined with azatoxin, camptothecin or cisplatin and underwent in vitro cytotoxicity analysis toward HT-29 and NCI-H1229 cancer cell lines. The methylated salan derivative exhibited synergistic effects with cisplatin at varying ratios toward both lines, when the compounds were administered fresh and simultaneously, implying great medicinal potential.

Original language	English
Pages (from-to)	7874-7879
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	11
DOIs	https://doi.org/10.1039/c4ra13484b
State	Published - 2015

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Publisher Copyright:
© The Royal Society of Chemistry 2015.

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Anti-proliferative activity of the combination of salan Ti(IV) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: Synergism with cisplatin

Abstract

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