Antibacterial and anti-inflammatory activities of 4-Hydroxycordoin: Potential therapeutic benefits

Mark Feldman, Shinichi Tanabe, Francesco Epifano, Salvatore Genovese, Massimo Curini, Daniel Grenier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


4-Hydroxycordoin (1), a natural isopentenyloxychalcone, is a plant secondary metabolite that is relatively rare. Since there are very few reports about the biological activities of 1, its potential benefits for periodontal disease were investigated. A marked and dose-dependent antibacterial activity of 1 was observed against the three major periodontal pathogens, Porphyromonas gingiValis, Fusobacterium nucleatum, and PreVotella intermedia. Moreover, compound 1 showed an antiadhesion effect, since it inhibited attachment of P. gingiValis to oral epithelial cells. Finally, using a macrophage model, the ability of 1 to inhibit the secretion of inflammatory mediators induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide was demonstrated. The anti-inflammatory effect observed was associated with reduced activation of the nuclear factor-kB (NF-kB) p65 and activator protein-1 (AP-1) pathways.

Original languageAmerican English
Pages (from-to)26-31
Number of pages6
JournalJournal of Natural Products
Issue number1
StatePublished - 28 Jan 2011
Externally publishedYes


Dive into the research topics of 'Antibacterial and anti-inflammatory activities of 4-Hydroxycordoin: Potential therapeutic benefits'. Together they form a unique fingerprint.

Cite this