TY - JOUR
T1 - Antibacterial dental resin composites
AU - Beyth, Nurit
AU - Farah, Shady
AU - Domb, Abraham J.
AU - Weiss, Ervin I.
PY - 2014/2
Y1 - 2014/2
N2 - Resin composite materials exhibit good esthetic properties and strength, making them the most commonly used materials for restoring hard tissue, i.e., enamel and dentin. In the last 30 years these restorative materials have been widely used for both anterior and posterior restorations. Regrettably, studies have indicated numerous failures, the main reason for which is secondary caries. Resin composites were found to accumulate more dental plaque than enamel and other restorations. Thus, to increase the service life of resin composite restorations, modifications introducing antibacterial properties are required. In this review the authors discuss the advantages and disadvantages of various released and non-released antibacterial agents incorporated in resin composites. A change in strategy based on the use of antimicrobial polymeric macromolecules is suggested, focusing on polycationic antimicrobials. Polyethyleneimine nanoparticles, in particular, are presented as a possible solution to the disadvantages of released antiseptic agents. Developing agents with strong antimicrobial activity upon contact that do not diminish over time nor affect the biocompatibility of materials should be the focus of future research.
AB - Resin composite materials exhibit good esthetic properties and strength, making them the most commonly used materials for restoring hard tissue, i.e., enamel and dentin. In the last 30 years these restorative materials have been widely used for both anterior and posterior restorations. Regrettably, studies have indicated numerous failures, the main reason for which is secondary caries. Resin composites were found to accumulate more dental plaque than enamel and other restorations. Thus, to increase the service life of resin composite restorations, modifications introducing antibacterial properties are required. In this review the authors discuss the advantages and disadvantages of various released and non-released antibacterial agents incorporated in resin composites. A change in strategy based on the use of antimicrobial polymeric macromolecules is suggested, focusing on polycationic antimicrobials. Polyethyleneimine nanoparticles, in particular, are presented as a possible solution to the disadvantages of released antiseptic agents. Developing agents with strong antimicrobial activity upon contact that do not diminish over time nor affect the biocompatibility of materials should be the focus of future research.
KW - Antibacterial polymer
KW - Nanoparticles
KW - Polyethyleneimine
KW - Resin composites
UR - http://www.scopus.com/inward/record.url?scp=84893189609&partnerID=8YFLogxK
U2 - 10.1016/j.reactfunctpolym.2013.11.011
DO - 10.1016/j.reactfunctpolym.2013.11.011
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:84893189609
SN - 1381-5148
VL - 75
SP - 81
EP - 88
JO - Reactive and Functional Polymers
JF - Reactive and Functional Polymers
IS - 1
ER -