Antibiotic susceptibility of Cutibacterium acnes strains isolated from Israeli acne patients

Sivan Sheffer-Levi*, Amit Rimon, Vanda Lerer, Tehila Shlomov, Shunit Coppenhagen-Glazer, Chani Rakov, Tamara Zeiter, Ran Nir-Paz, Ronen Hazan, Vered Molho-Pessach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Antibiotic-resistant Cutibacterium acnes has been reported worldwide, but data from Israeli patients with acne is currently lacking. This study evaluated the antibiotic susceptibility of C. acnes, isolated from 50 Israeli patients with acne to commonly prescribed antibiotics, using the Epsilometer test (E-test). Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis, 16S rRNA sequencing and single locus sequence typing (SLST) molecular typing were used to identify and characterize C. acnes. Among 36 strains isolated, phylotype IA1 was most common. Resistance to at least one antibiotic was found in 30.6% of tested strains. Resistance rates were highest for erythromycin (25.0%), followed by doxycycline (19.4%), clindamycin (16.7%), minocycline (11.1%) and tetracycline (8.3%). Significant correlation was found between resistance to multiple antibiotics, with 5.6% of isolates resistant to all antibiotics tested. When reviewing resistances rate worldwide antibiotic resistance was found to be prevalent in Israel. Measures to limit the emergence of antibiotic-resistant strains of Cutibacterium acnes should be taken and alternative treatments should be sought.

Original languageAmerican English
Article numberadv00295
Pages (from-to)1-8
Number of pages8
JournalActa Dermato-Venereologica
Issue number17
StatePublished - 2020

Bibliographical note

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© 2020, Medical Journals/Acta D-V. All rights reserved.


  • Acne
  • Antibiotic
  • Cutibacterium acnes
  • Resistance


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