TY - JOUR
T1 - Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen
AU - Puri, Joseph
AU - Ben‐Neriah, Yinon
AU - Givol, David
AU - Lonai, Peter
PY - 1980/4
Y1 - 1980/4
N2 - The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.
AB - The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.
UR - http://www.scopus.com/inward/record.url?scp=0018854663&partnerID=8YFLogxK
U2 - 10.1002/eji.1830100411
DO - 10.1002/eji.1830100411
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C2 - 6156844
AN - SCOPUS:0018854663
SN - 0014-2980
VL - 10
SP - 281
EP - 284
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 4
ER -
