Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen

Joseph Puri, Yinon Ben‐Neriah, David Givol, Peter Lonai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.

Original languageAmerican English
Pages (from-to)281-284
Number of pages4
JournalEuropean Journal of Immunology
Volume10
Issue number4
DOIs
StatePublished - Apr 1980

Fingerprint

Dive into the research topics of 'Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen'. Together they form a unique fingerprint.

Cite this