Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen

Joseph Puri; Yinon Ben‐Neriah; David Givol; Peter Lonai

doi:10.1002/eji.1830100411

Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen

Joseph Puri
, Yinon Ben‐Neriah
, David Givol
, Peter Lonai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated V_H and V_L fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐V_H, but not anti‐V_γ, or anti‐V_χ, inhibited suicide of carrier‐ primed cells.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	European Journal of Immunology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/eji.1830100411
State	Published - Apr 1980
Externally published	Yes

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10.1002/eji.1830100411

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title = "Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen",

abstract = "The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.",

author = "Joseph Puri and Yinon Ben‐Neriah and David Givol and Peter Lonai",

year = "1980",

month = apr,

doi = "10.1002/eji.1830100411",

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AU - Puri, Joseph

AU - Ben‐Neriah, Yinon

AU - Givol, David

AU - Lonai, Peter

PY - 1980/4

Y1 - 1980/4

N2 - The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.

AB - The antigen‐binding receptor of helper T cells was studied by radioactive antigen‐ caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti‐VH, but not anti‐Vγ, or anti‐Vχ, inhibited suicide of carrier‐ primed cells.

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C2 - 6156844

AN - SCOPUS:0018854663

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JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 4

ER -

Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen

Abstract

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