TY - JOUR
T1 - Antibody response to influenza immunization in patients after heart transplantation
AU - Admon, D.
AU - Engelhard, D.
AU - Strauss, N.
AU - Goldman, N.
AU - Zakay-Rones, Z.
PY - 1997/10
Y1 - 1997/10
N2 - The aim of this study was to evaluate post-heart transplantation (Htx) response to two-dose and three-dose influenza vaccine. Hemagglutination inhibition antibodies were monitored in HTx recipients immunized twice (n = 25) or three times (n = 17), and non-HTx controls (n = 8) once, with inactivated influenza vaccine, Post-first dose protective antibody titers (≤1:40) were demonstrated in 9/25 (36%) for A/Singapore/(H1N1), 5/25 (20%) for A/Shanghai/(H3N2) and 2/25 (8%) for B/Yamagata compared with 4/8 (50%), 6/8 (75%) and 2/8 (25%), respectively, for controls. Post-second dose protective titers remained low, increasing following the third dose to 71%, 65% and 29%, respectively. The abnormally low antibody responses of HTx recipients to one-dose and two-dose influenza vaccine can be overcome by a third dose.
AB - The aim of this study was to evaluate post-heart transplantation (Htx) response to two-dose and three-dose influenza vaccine. Hemagglutination inhibition antibodies were monitored in HTx recipients immunized twice (n = 25) or three times (n = 17), and non-HTx controls (n = 8) once, with inactivated influenza vaccine, Post-first dose protective antibody titers (≤1:40) were demonstrated in 9/25 (36%) for A/Singapore/(H1N1), 5/25 (20%) for A/Shanghai/(H3N2) and 2/25 (8%) for B/Yamagata compared with 4/8 (50%), 6/8 (75%) and 2/8 (25%), respectively, for controls. Post-second dose protective titers remained low, increasing following the third dose to 71%, 65% and 29%, respectively. The abnormally low antibody responses of HTx recipients to one-dose and two-dose influenza vaccine can be overcome by a third dose.
KW - Heart transplantation immunization
KW - Immunocompromised immunization
KW - Influenza virus immunization
UR - http://www.scopus.com/inward/record.url?scp=0030803740&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(97)00193-X
DO - 10.1016/S0264-410X(97)00193-X
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C2 - 9330462
AN - SCOPUS:0030803740
SN - 0264-410X
VL - 15
SP - 1518
EP - 1522
JO - Vaccine
JF - Vaccine
IS - 14
ER -