TY - JOUR
T1 - Anticariogenic activity of licorice and glycyrrhizine I
T2 - Inhibition of in vitro plaque formation by Streptococcus mutans
AU - Segal, R.
AU - Pisanty, S.
AU - Wormser, R.
AU - Azaz, E.
AU - Sela, M. N.
PY - 1985/1
Y1 - 1985/1
N2 - The effect of licorice and its active sweet component glycyrrhizin was tested on the growth and adherence to glass of the cariogenic Streptococcus mutans. Neither licorice nor glycyrrhizin promoted growth or induced plaque formation. In the presence of sucrose, glycyrrhizin did not affect bacterial growth, but the adherence (plaque formation) was markedly inhibited. At 0.5–1% glycyrrhizin, inhibition was almost complete. These results support our previous suggestions that glycyrrhizin might serve as an efficient vehicle for topical oral medications.
AB - The effect of licorice and its active sweet component glycyrrhizin was tested on the growth and adherence to glass of the cariogenic Streptococcus mutans. Neither licorice nor glycyrrhizin promoted growth or induced plaque formation. In the presence of sucrose, glycyrrhizin did not affect bacterial growth, but the adherence (plaque formation) was markedly inhibited. At 0.5–1% glycyrrhizin, inhibition was almost complete. These results support our previous suggestions that glycyrrhizin might serve as an efficient vehicle for topical oral medications.
UR - https://www.scopus.com/pages/publications/0021964558
U2 - 10.1002/jps.2600740121
DO - 10.1002/jps.2600740121
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C2 - 3981425
AN - SCOPUS:0021964558
SN - 0022-3549
VL - 74
SP - 79
EP - 81
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 1
ER -