Abstract
Administration of antidiuretic hormone to rats at a dose of 400 or 40 mu/100 g i.m. caused a significant fall in plasma renin concentration. (PRC). In male rats with diabetes insipidus, a significant elevation of both plasma and kidney renin concentrations was not significantly different from that in control female rats. Ovariectomy did not abolish this difference between female and male rats with hereditary diabetes insipidus. Plasma angiotensinogen (renin substrate) was significantly higher in male rats compared to females but no difference between rats with and without diabetes insipidus was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 114-118 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1974 |
Keywords
- ADH
- Angiotensinogen
- Diabetes insipidus
- Renin
- kidney
