Antiepileptic drugs modify power of high EEG frequencies and their neural generators

S. Arzy*, G. Allali, D. Brunet, C. M. Michel, P. W. Kaplan, M. Seeck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Background: The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology. Methods: Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, carbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group. Results: Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions. Conclusion: Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology.

Original languageAmerican English
Pages (from-to)1308-1312
Number of pages5
JournalEuropean Journal of Neurology
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • anterior temporal cortex
  • antiepileptic drugs
  • gamma band
  • inferior frontal cortex


Dive into the research topics of 'Antiepileptic drugs modify power of high EEG frequencies and their neural generators'. Together they form a unique fingerprint.

Cite this