TY - JOUR
T1 - Antigen non-specific activities in culture supernatant of ovalbumin-specific, cloned helper T lymphoma
AU - Yefenof, E.
AU - Feinmani, Rena
AU - Kedar, E.
PY - 1985
Y1 - 1985
N2 - Antigen non-specific activities in culture supernatants from clones of a radiation leukemia virus transformed, ovalbumin-specific helper T lymphoma were studied. After stimulation with ovalbumin-pulsed macrophages, these clones release factor(s) capable of providing carrier-specific help for anti-hapten antibody responses. It was found that in addition to IL 2-likeactivity, one clone constitutively released a suppressive factor that could inhibit polyclonal growth and differentiation of B cells stimulated with LPS. The factor inhibited activation of both syngeneic and allogeneic B cells directly, rather than via activation of accessory suppressor T lymphocytes. However, upon dilution of the supernatant, B cell growth and differentiation activities were detected. A role for a polyclonal B cell suppressor factor in the overall helper activity of the clone is proposed.
AB - Antigen non-specific activities in culture supernatants from clones of a radiation leukemia virus transformed, ovalbumin-specific helper T lymphoma were studied. After stimulation with ovalbumin-pulsed macrophages, these clones release factor(s) capable of providing carrier-specific help for anti-hapten antibody responses. It was found that in addition to IL 2-likeactivity, one clone constitutively released a suppressive factor that could inhibit polyclonal growth and differentiation of B cells stimulated with LPS. The factor inhibited activation of both syngeneic and allogeneic B cells directly, rather than via activation of accessory suppressor T lymphocytes. However, upon dilution of the supernatant, B cell growth and differentiation activities were detected. A role for a polyclonal B cell suppressor factor in the overall helper activity of the clone is proposed.
UR - http://www.scopus.com/inward/record.url?scp=0021842489&partnerID=8YFLogxK
U2 - 10.1016/S0171-2985(85)80006-1
DO - 10.1016/S0171-2985(85)80006-1
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C2 - 2931349
AN - SCOPUS:0021842489
SN - 0171-2985
VL - 169
SP - 520
EP - 531
JO - Immunobiology
JF - Immunobiology
IS - 5
ER -