TY - JOUR
T1 - Antigen presentation by proliferating thymic macrophages to a (T,G)-A-L specific T cell line in an H-2 restricted manner
AU - Axelrod, Ofra
AU - Mozes, Edna
AU - Gallily, Ruth
PY - 1985
Y1 - 1985
N2 - Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.
AB - Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.
KW - antigen presentation
KW - antigen-specific T cell line
KW - H-2 restriction
KW - T cell proliferation
KW - thymus-derived macrophages
UR - http://www.scopus.com/inward/record.url?scp=0021882002&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(85)90045-8
DO - 10.1016/0165-2478(85)90045-8
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C2 - 3874152
AN - SCOPUS:0021882002
SN - 0165-2478
VL - 10
SP - 25
EP - 30
JO - Immunology Letters
JF - Immunology Letters
IS - 1
ER -