Antigen presentation by proliferating thymic macrophages to a (T,G)-A-L specific T cell line in an H-2 restricted manner

Ofra Axelrod; Edna Mozes; Ruth Gallily

doi:10.1016/0165-2478(85)90045-8

Antigen presentation by proliferating thymic macrophages to a (T,G)-A-L specific T cell line in an H-2 restricted manner

Ofra Axelrod
, Edna Mozes^*
, Ruth Gallily

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

Abstract

Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.

Original language	English
Pages (from-to)	25-30
Number of pages	6
Journal	Immunology Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(85)90045-8
State	Published - 1985

Keywords

H-2 restriction
T cell proliferation
antigen presentation
antigen-specific T cell line
thymus-derived macrophages

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10.1016/0165-2478(85)90045-8

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title = "Antigen presentation by proliferating thymic macrophages to a (T,G)-A-L specific T cell line in an H-2 restricted manner",

abstract = "Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.",

keywords = "H-2 restriction, T cell proliferation, antigen presentation, antigen-specific T cell line, thymus-derived macrophages",

author = "Ofra Axelrod and Edna Mozes and Ruth Gallily",

year = "1985",

doi = "10.1016/0165-2478(85)90045-8",

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AU - Mozes, Edna

AU - Gallily, Ruth

PY - 1985

Y1 - 1985

N2 - Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.

AB - Long-term cultures of murine homogeneous populations of Ia-bearing thymus-derived murine macrophages were tested for their ability to present antigen to a (T,G)-A-L specific IL-2-dependent continuous T cell line. Thymus-derived macrophages, with and without pretreatment for Ia induction, triggered efficiently antigen-specific T cell proliferation in an MHC restricted way. This experimental system, consisting of two normal proliferating homogeneous populations of macrophages and antigen specific T cells, provides an ideal tool for studying the mechanism of antigen presentation to T cells and for elucidation of the role of macrophages in T-B cell collaboration for antibody production.

KW - H-2 restriction

KW - T cell proliferation

KW - antigen presentation

KW - antigen-specific T cell line

KW - thymus-derived macrophages

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Antigen presentation by proliferating thymic macrophages to a (T,G)-A-L specific T cell line in an H-2 restricted manner

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Keywords

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