Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen; Uri Hershberg; Sorin Solomon

doi:10.1016/j.molimm.2003.11.020

Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen^*, Uri Hershberg, Sorin Solomon

^*Corresponding author for this work

Racah Institute of Physics

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

Original language	English
Pages (from-to)	993-996
Number of pages	4
Journal	Molecular Immunology
Volume	40
Issue number	14-15
DOIs	https://doi.org/10.1016/j.molimm.2003.11.020
State	Published - Feb 2004

Keywords

Clonal selection
Cognitive paradigm
Degeneracy
Inflammation
Specificity
T cells
T-cell receptor

Access to Document

10.1016/j.molimm.2003.11.020

Cite this

@article{63630a42acee47b78731ff46b17845c0,

title = "Antigen-receptor degeneracy and immunological paradigms",

abstract = "This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.",

keywords = "Clonal selection, Cognitive paradigm, Degeneracy, Inflammation, Specificity, T cells, T-cell receptor",

author = "Cohen, {Irun R.} and Uri Hershberg and Sorin Solomon",

year = "2004",

month = feb,

doi = "10.1016/j.molimm.2003.11.020",

language = "אנגלית",

volume = "40",

pages = "993--996",

journal = "Molecular Immunology",

issn = "0161-5890",

publisher = "Elsevier Ltd.",

number = "14-15",

}

TY - JOUR

T1 - Antigen-receptor degeneracy and immunological paradigms

AU - Cohen, Irun R.

AU - Hershberg, Uri

AU - Solomon, Sorin

PY - 2004/2

Y1 - 2004/2

N2 - This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

AB - This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

KW - Clonal selection

KW - Cognitive paradigm

KW - Degeneracy

KW - Inflammation

KW - Specificity

KW - T cells

KW - T-cell receptor

UR - http://www.scopus.com/inward/record.url?scp=1242270600&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2003.11.020

DO - 10.1016/j.molimm.2003.11.020

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 15036901

AN - SCOPUS:1242270600

SN - 0161-5890

VL - 40

SP - 993

EP - 996

JO - Molecular Immunology

JF - Molecular Immunology

IS - 14-15

ER -

Antigen-receptor degeneracy and immunological paradigms

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this