Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen; Uri Hershberg; Sorin Solomon

doi:10.1016/j.molimm.2003.11.020

Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen^*, Uri Hershberg, Sorin Solomon

^*Corresponding author for this work

Racah Institute of Physics

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38 Scopus citations

Abstract

This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

Original language	English
Pages (from-to)	993-996
Number of pages	4
Journal	Molecular Immunology
Volume	40
Issue number	14-15
DOIs	https://doi.org/10.1016/j.molimm.2003.11.020
State	Published - Feb 2004

Keywords

Clonal selection
Cognitive paradigm
Degeneracy
Inflammation
Specificity
T cells
T-cell receptor

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10.1016/j.molimm.2003.11.020

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abstract = "This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.",

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KW - Cognitive paradigm

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KW - Inflammation

KW - Specificity

KW - T cells

KW - T-cell receptor

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Antigen-receptor degeneracy and immunological paradigms

Abstract

Keywords

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