TY - JOUR
T1 - Antigen-specific immune response impairment in the chick as influenced by dietary vitamin A
AU - Friedman, A.
AU - Sklan, D.
PY - 1989
Y1 - 1989
N2 - The effects of a broad range of dietary viramin A levels on antigen-specific immune responses of the chick were studied. Vitamin A deficiency and long-term excess caused impairment of the immune response as demonstrated by antigen-specific antibody production and T-lymphocyte proliferation in vitro. Immune responsiveness was correlated with both hepatic and blood vitamin A levels, and was affected prior to other physiological manifestations of hypo- or hypervitaminosis. In contrast to the effects of long-term vitamin excess, a large vitamin A bolus did not cause immune response impairment and, on the contrary, restored normal immune functions in previously vitamin A-depleted chicks. This finding implied a regulatory role for vitamin A in the immune system rather than a constitutive one.
AB - The effects of a broad range of dietary viramin A levels on antigen-specific immune responses of the chick were studied. Vitamin A deficiency and long-term excess caused impairment of the immune response as demonstrated by antigen-specific antibody production and T-lymphocyte proliferation in vitro. Immune responsiveness was correlated with both hepatic and blood vitamin A levels, and was affected prior to other physiological manifestations of hypo- or hypervitaminosis. In contrast to the effects of long-term vitamin excess, a large vitamin A bolus did not cause immune response impairment and, on the contrary, restored normal immune functions in previously vitamin A-depleted chicks. This finding implied a regulatory role for vitamin A in the immune system rather than a constitutive one.
UR - http://www.scopus.com/inward/record.url?scp=0024332266&partnerID=8YFLogxK
U2 - 10.1093/jn/119.5.790
DO - 10.1093/jn/119.5.790
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C2 - 2786059
AN - SCOPUS:0024332266
SN - 0022-3166
VL - 119
SP - 790
EP - 795
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 5
ER -