Antigenic modulation

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Abstract

The attachment of antibodies to antigens of the cell surface may lead to alteration of the distribution and expression of the antigens. The disappearance of antigens from the cell surface, following exposure to antibodies, is called antigenic modulation. This phenomenon was documented for the TL antigens of mouse thymus and leukemia cells, for immunoglobulin determinants of B lymphocytes, and for the H 2 antigens on the surface of murine peritoneal cells. Antigenic modulation is the result of an active response of living cells to the attachment of antibodies, and can be prevented by exposure of the cells of various metabolic inhibitors. Antigenic modulation may result from pinocytosis of complexes of antibodies and cell surface antigens.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalBiomedicine (India)
Volume18
Issue number6
StatePublished - 1973

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