Antigenic variation by protozoan parasites: Insights from Babesia bovis

Ron Dzikowski, Kirk Deitsch*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations


Antigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long-term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface antigen, a protein called VESA1. In this issue, Al-Khedery and Allred provide a detailed description of the genes that encode VESA1 and present convincing evidence for progressive, segmental gene conversion in the generation of variant forms of this surface antigen.

Original languageAmerican English
Pages (from-to)364-366
Number of pages3
JournalMolecular Microbiology
Issue number2
StatePublished - Jan 2006
Externally publishedYes


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