Antimalarial drugs: Is the lysosomotropic hypothesis still valid?

H. Ginsburg

doi:10.1016/0169-4758(90)90178-7

Antimalarial drugs: Is the lysosomotropic hypothesis still valid?

H. Ginsburg^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Although quinine and its congener chloroquine have been used as antimalarials for many years, and their analog, mefloquine, has been recently introduced, the precise mode of action of these quinoline-containing drugs is not fully understood. The lysosomotropic hypothesis is favoured^1,2 and Hagai Ginsburg here discusses its principles and its reliability in view of both the physicochemical character of the drugs and new experimental evidence.

Original language	English
Pages (from-to)	334-337
Number of pages	4
Journal	Parasitology Today
Volume	6
Issue number	10
DOIs	https://doi.org/10.1016/0169-4758(90)90178-7
State	Published - Oct 1990

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10.1016/0169-4758(90)90178-7

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Antimalarial drugs: Is the lysosomotropic hypothesis still valid?

Abstract

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