TY - JOUR
T1 - Antimalarial properties of soy-bean fat emulsions
AU - Deharo, E.
AU - Krugliak, M.
AU - Baccam, D.
AU - Ginsburg, H.
PY - 1995/12
Y1 - 1995/12
N2 - Intralipid® and Ivelip® are commercial preparations of soy-bean lipid extracts used for intravenous supplementation of lipids in various clinical conditions. They were found to inhibit the growth of Plasmodium falciparum in culture with an IC50 of 8.07 ± 2.13 and 13.32 ± 2.05 mg.ml-1, respectively. Intralipid® rapidly and efficiently inhibited nucleic acid synthesis in cultured P. falciparum, exhibiting full inhibitory activity in less than 2 h. Ivelip® injected intraperitoneally, was found by the 4-day suppressive test to be active in vivo against P. vinckei petteri within the normal recommended regimen for dietary lipid supply (0.5-4 g.kg-1), but it was impossible to obtain a radical cure even with very high doses (6.4 g.kg-1). Ivelip® was less effective against P. berghei and P. yoelii nigeriensis. As Ivelip® showed no interference with the antimalarial activity of chloroquine, it could be considered for use in the treatment of severe human malaria in association with 4-aminoquinolines to expedite the clearance of parasites.
AB - Intralipid® and Ivelip® are commercial preparations of soy-bean lipid extracts used for intravenous supplementation of lipids in various clinical conditions. They were found to inhibit the growth of Plasmodium falciparum in culture with an IC50 of 8.07 ± 2.13 and 13.32 ± 2.05 mg.ml-1, respectively. Intralipid® rapidly and efficiently inhibited nucleic acid synthesis in cultured P. falciparum, exhibiting full inhibitory activity in less than 2 h. Ivelip® injected intraperitoneally, was found by the 4-day suppressive test to be active in vivo against P. vinckei petteri within the normal recommended regimen for dietary lipid supply (0.5-4 g.kg-1), but it was impossible to obtain a radical cure even with very high doses (6.4 g.kg-1). Ivelip® was less effective against P. berghei and P. yoelii nigeriensis. As Ivelip® showed no interference with the antimalarial activity of chloroquine, it could be considered for use in the treatment of severe human malaria in association with 4-aminoquinolines to expedite the clearance of parasites.
KW - drug
KW - malaria
KW - P. berghei
KW - P. vinckei petteri
KW - P. yoelii nigeriensis
KW - Plasmodium falciparum
KW - soy-bean fat emulsion
UR - http://www.scopus.com/inward/record.url?scp=0028806655&partnerID=8YFLogxK
U2 - 10.1016/0020-7519(95)00084-4
DO - 10.1016/0020-7519(95)00084-4
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C2 - 8719958
AN - SCOPUS:0028806655
SN - 0020-7519
VL - 25
SP - 1457
EP - 1462
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 12
ER -
