Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network

Shady Farah; Oren Aviv; Natalia Laout; Stanislav Ratner; Nurit Beyth; Abraham J. Domb

doi:10.1002/pat.3260

Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network

Shady Farah
, Oren Aviv
, Natalia Laout
, Stanislav Ratner
, Nurit Beyth
, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S-QA-PEI). The synthesized S-QA-PEI particles were identified with a slight particle size increase of 2-3μm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, -16.7±5.11mV, the prepared S-QA-PEI particles are positively charged, +50-60mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity.

Original language	English
Pages (from-to)	689-692
Number of pages	4
Journal	Polymers for Advanced Technologies
Volume	25
Issue number	6
DOIs	https://doi.org/10.1002/pat.3260
State	Published - 1 Jun 2014

Bibliographical note

Publisher Copyright:
© 2014 John Wiley & Sons, Ltd.

Keywords

Antimicrobial surface
Interpenetrating polymer network
Polyethylenimine (PEI)
Silica particles

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10.1002/pat.3260

Cite this

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title = "Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network",

abstract = "Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S-QA-PEI). The synthesized S-QA-PEI particles were identified with a slight particle size increase of 2-3μm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, -16.7±5.11mV, the prepared S-QA-PEI particles are positively charged, +50-60mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity.",

keywords = "Antimicrobial surface, Interpenetrating polymer network, Polyethylenimine (PEI), Silica particles",

author = "Shady Farah and Oren Aviv and Natalia Laout and Stanislav Ratner and Nurit Beyth and Domb, \{Abraham J.\}",

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doi = "10.1002/pat.3260",

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T1 - Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network

AU - Farah, Shady

AU - Aviv, Oren

AU - Laout, Natalia

AU - Ratner, Stanislav

AU - Beyth, Nurit

AU - Domb, Abraham J.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S-QA-PEI). The synthesized S-QA-PEI particles were identified with a slight particle size increase of 2-3μm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, -16.7±5.11mV, the prepared S-QA-PEI particles are positively charged, +50-60mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity.

AB - Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S-QA-PEI). The synthesized S-QA-PEI particles were identified with a slight particle size increase of 2-3μm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, -16.7±5.11mV, the prepared S-QA-PEI particles are positively charged, +50-60mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity.

KW - Antimicrobial surface

KW - Interpenetrating polymer network

KW - Polyethylenimine (PEI)

KW - Silica particles

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EP - 692

JO - Polymers for Advanced Technologies

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Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network

Abstract

Bibliographical note

Keywords

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