TY - JOUR
T1 - Antioxidant and antiproliferative effects of methanol extracts from raw and fermented parts of mulberry plant (Morus alba L.)
AU - Chon, Sang Uk
AU - Kim, Young Min
AU - Park, Yun Jum
AU - Heo, Buk Gu
AU - Park, Yong Seo
AU - Gorinstein, Shela
PY - 2009/11
Y1 - 2009/11
N2 - Total phenolic content, phenolic acids, radical scavenging activity and antiproliferative properties of different parts of mulberry (Morus alba L.) were determined. The highest phenolic content was found in methanol extracts of mulberry root (117.7 ± 2.0), followed by leaves (71.4 ± 2.4), branches (49.0 ± 1.5) and fruit (11.2 ± 0.3) [mg ferulic acid equivalents (FAE) kg-1 dry weight (DW)] (P < 0.05). The highest level of total phenolics in the fractions was in roots (166.2 ± 7.5 and 160.8 ± 7.2 mg kg-1 DW for BuOH and EtOAC, respectively). Methanol extracts and their fractions dose dependently increased radical scavenging activity of mulberry branches, roots and leafs (more than 70%). Total phenolic content of the tested plant extracts was highly correlated with the radical scavenging activity. The antiproliferative effect of mulberry parts on human cell lines was different and connected to the concentrations of the investigated extracts. The fermentation of the mulberry leaves did increase their methanol extract antiproliferative effect only on human gastric carcinoma (SNU-601) cell line in concentration of 1,000 mg mL-1. In conclusion, some plant parts of the Korean mulberry could be recommended as preventative and therapeutic agents, based on their antioxidant and antiproliferative properties.
AB - Total phenolic content, phenolic acids, radical scavenging activity and antiproliferative properties of different parts of mulberry (Morus alba L.) were determined. The highest phenolic content was found in methanol extracts of mulberry root (117.7 ± 2.0), followed by leaves (71.4 ± 2.4), branches (49.0 ± 1.5) and fruit (11.2 ± 0.3) [mg ferulic acid equivalents (FAE) kg-1 dry weight (DW)] (P < 0.05). The highest level of total phenolics in the fractions was in roots (166.2 ± 7.5 and 160.8 ± 7.2 mg kg-1 DW for BuOH and EtOAC, respectively). Methanol extracts and their fractions dose dependently increased radical scavenging activity of mulberry branches, roots and leafs (more than 70%). Total phenolic content of the tested plant extracts was highly correlated with the radical scavenging activity. The antiproliferative effect of mulberry parts on human cell lines was different and connected to the concentrations of the investigated extracts. The fermentation of the mulberry leaves did increase their methanol extract antiproliferative effect only on human gastric carcinoma (SNU-601) cell line in concentration of 1,000 mg mL-1. In conclusion, some plant parts of the Korean mulberry could be recommended as preventative and therapeutic agents, based on their antioxidant and antiproliferative properties.
KW - Antiproliferative effect
KW - Mulberry plant parts
KW - Phenolic acids
KW - Radical scavenging activity
KW - Total phenolics
UR - http://www.scopus.com/inward/record.url?scp=76149123183&partnerID=8YFLogxK
U2 - 10.1007/s00217-009-1165-2
DO - 10.1007/s00217-009-1165-2
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AN - SCOPUS:76149123183
SN - 1438-2377
VL - 230
SP - 231
EP - 237
JO - European Food Research and Technology
JF - European Food Research and Technology
IS - 2
ER -