Antiprogestins: modulators in reproduction

Irving M. Spitz*, Israel Agranat

*Corresponding author for this work

Research output: Contribution to specialist publicationArticle

5 Scopus citations

Abstract

Mifepristone, the first antiprogesterone to be developed was discovered in 1981 and was originally called RU 38486. Unlike natural occurring hormones, mifepristone inhibits the effects of progesterone and cortisol, hence acting as a potent progestin and glucocorticoid antagonist. Mifepristone is a safe and effective drug for abortion and thus have a marked impact on maternal health throughout the world. However, abortion is not the only application of this new group of compounds, they can also be used to treat patients suffering from hormone dependent tumors, gynecological disorders and for contraception.

Original languageEnglish
Pages89-92
Number of pages4
No3
Specialist publicationChemistry and Industry (London)
StatePublished - 6 Feb 1995
Externally publishedYes

Fingerprint

Dive into the research topics of 'Antiprogestins: modulators in reproduction'. Together they form a unique fingerprint.

Cite this