TY - JOUR
T1 - Antiviral activity of SK&F 21681 against herpes simplex virus
AU - Katz, E.
AU - Margalith, E.
PY - 1984
Y1 - 1984
N2 - SK&F21681(3,10-dimethyl-10-H-s-triazolo[4',3':2,3]-as-triazino-[5,6-b]indole) is an inhibitor of the growth of herpes simplex viruses types 1 and 2 at a concentration of 60 μg/ml. It inhibits the synthesis of the viral DNA and the formation of virus particles, although the viral polypeptide synthesis is not significantly affected by this compound. Mutants of herpes simplex viruses types 1 and 2 which are able to grow in the presence of SK&F 21681 were isolated. They induced normal levels of thymidine kinase and DNA polymerase activities in the infected cells and did not show resistance to either 9-[2-hydroxyethoxymethyl]guanine or phosphonoacetic acid.
AB - SK&F21681(3,10-dimethyl-10-H-s-triazolo[4',3':2,3]-as-triazino-[5,6-b]indole) is an inhibitor of the growth of herpes simplex viruses types 1 and 2 at a concentration of 60 μg/ml. It inhibits the synthesis of the viral DNA and the formation of virus particles, although the viral polypeptide synthesis is not significantly affected by this compound. Mutants of herpes simplex viruses types 1 and 2 which are able to grow in the presence of SK&F 21681 were isolated. They induced normal levels of thymidine kinase and DNA polymerase activities in the infected cells and did not show resistance to either 9-[2-hydroxyethoxymethyl]guanine or phosphonoacetic acid.
UR - http://www.scopus.com/inward/record.url?scp=0021347597&partnerID=8YFLogxK
U2 - 10.1128/AAC.25.2.195
DO - 10.1128/AAC.25.2.195
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C2 - 6324667
AN - SCOPUS:0021347597
SN - 0066-4804
VL - 25
SP - 195
EP - 200
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -