TY - JOUR
T1 - Antiviral compounds. 3. The preparation of some diketophosphonates derived from sugars
AU - Breuer, E.
AU - Melumad, D.
AU - Sarel So, So
AU - Katz, E.
PY - 1983
Y1 - 1983
N2 - 3-[2',4'-O-benzylidene-3',5'-di'O-benzoyl-D-ribosylidene]2,4-pentanedione 3 and 3[2',4': 3',5'-di-O-benzylidene-D-ribosylidene]2,4-pentanedione 5 were converted by reaction with trimethyl phosphate to diketophosphonates 4 and 6 respectively. While compound 4 showed antiviral activity similar to 3 with lower toxicity, compound 6 was devoid of antiviral activity as well as cytotoxicity.
AB - 3-[2',4'-O-benzylidene-3',5'-di'O-benzoyl-D-ribosylidene]2,4-pentanedione 3 and 3[2',4': 3',5'-di-O-benzylidene-D-ribosylidene]2,4-pentanedione 5 were converted by reaction with trimethyl phosphate to diketophosphonates 4 and 6 respectively. While compound 4 showed antiviral activity similar to 3 with lower toxicity, compound 6 was devoid of antiviral activity as well as cytotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=0021059391&partnerID=8YFLogxK
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AN - SCOPUS:0021059391
SN - 0223-5234
VL - 18
SP - 487
EP - 488
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 6
ER -