Antiviral Polymers Based on N-Halamine Polyurea

Noam Y. Steinman, Tan Hu, Aviv Dombrovsky, Meital Reches, Abraham J. Domb*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

N-halamines are a commonly applied class of antimicrobial agents used for a variety of applications relating to human health. Here, we present the modulation of the common polymers polyurea and polyguanidine with the N-halamine technology. The N-H bonds in either polymer were converted to N-Cl or N-Br bonds capable of releasing Cl+ or Br+ cations to aqueous media as antiviral agents. Controlled release of the oxidizing agents was monitored for a period of 4 weeks. Antiviral activity was evaluated against the T4 bacteriophage as well as against the highly stable plant virus belonging to the Tobamovirus genus, tomato brown rugose fruit virus. The incorporation of the N-halamine technology on commonly used polymers has effectively introduced antiviral functionality for a wide variety of potential applications.

Original languageAmerican English
Pages (from-to)4357-4364
Number of pages8
JournalBiomacromolecules
Volume22
Issue number10
DOIs
StatePublished - 11 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society.

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