Anxiety Disorders and Depression Comorbidity

Jonathan D. Huppert*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations


The chapter reviews cross-sectional and longitudinal epidemiological studies related to the co-occurrence of anxiety disorders and depression. Results suggest that anxiety disorders and depression tend to co-occur in 20% to 40% of patients. Explanations for increased co-occurrence considered include overlapping diagnostic criteria, genetics, neurophysiology, neurochemistry, negative affect/ temperament, perceived control, interpersonal mechanisms, and biases in information processing. According to most levels of analysis, there is more overlap with GAD and depression while specific phobias have the least overlap. Finally, data on the impact of depression on pharmacological and psychological treatments for anxiety disorders are reviewed. More work is needed to clarify the multiple interactive processes likely at play in the co-occurrence of anxiety and mood disorders and their treatment.

Original languageAmerican English
Title of host publicationOxford Handbook of Anxiety and Related Disorders
PublisherOxford University Press
ISBN (Electronic)9780199940141
ISBN (Print)9780195307030
StatePublished - 4 Sep 2008

Bibliographical note

Publisher Copyright:
© 2009 by Oxford University Press. All rights reserved.


  • Anxiety
  • Comorbidity
  • Depression
  • Neurophysiology
  • Phenomenology
  • Psychopathology
  • Treatment


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