AP-1 as a regulator of cell life and death

Eitan Shaulian, Michael Karin

Research output: Contribution to journalReview articlepeer-review

2350 Scopus citations


The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.

Original languageAmerican English
Pages (from-to)E131-E136
JournalNature Cell Biology
Issue number5
StatePublished - 2002


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