Apicoplast Dynamics During Plasmodium Cell Cycle

Arwa Elaagip, Sabrina Absalon*, Anat Florentin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The deadly malaria parasite, Plasmodium falciparum, contains a unique subcellular organelle termed the apicoplast, which is a clinically-proven antimalarial drug target. The apicoplast is a plastid with essential metabolic functions that evolved via secondary endosymbiosis. As an ancient endosymbiont, the apicoplast retained its own genome and it must be inherited by daughter cells during cell division. During the asexual replication of P. falciparum inside human red blood cells, both the parasite, and the apicoplast inside it, undergo massive morphological changes, including DNA replication and division. The apicoplast is an integral part of the cell and thus its development is tightly synchronized with the cell cycle. At the same time, certain aspects of its dynamics are independent of nuclear division, representing a degree of autonomy in organelle biogenesis. Here, we review the different aspects of organelle dynamics during P. falciparum intraerythrocytic replication, summarize our current understanding of these processes, and describe the many open questions in this area of parasite basic cell biology.

Original languageAmerican English
Article number864819
JournalFrontiers in Cellular and Infection Microbiology
Volume12
DOIs
StatePublished - 29 Apr 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Elaagip, Absalon and Florentin.

Keywords

  • apicoplast
  • cell cycle
  • malaria
  • organelle dynamics
  • plasmodium
  • schizogony

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