TY - JOUR
T1 - Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice
AU - Browning, Philip J.
AU - Roberts, David D.
AU - Zabrenetzky, Vivian
AU - Bryant, Joseph
AU - Kaplan, Mark
AU - Washington, Robyn H.
AU - Panet, Amos
AU - Gallo, Robert C.
AU - Vogel, Tikva
PY - 1994/11/1
Y1 - 1994/11/1
N2 - Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE- 3 also inhibited the formation of neoangiogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These findings represent a novel and potentially less toxic therapeutic approach for the treatment of AIDS-KS.
AB - Recombinant apolipoprotein E-3 (ApoE-3), expressed in Escherichia coli, was purified and used in an in vitro and an in vivo model system for acquired immunodeficiency syndrome-associated Kaposi's sarcoma (AIDS-KS). This protein blocked cell proliferation and chemotaxis of AIDS-KS cells in response to activated lymphocyte conditioned medium (AL-CM) and oncostatin M (OSM). ApoE- 3 also inhibited the formation of neoangiogenic lesions induced in BALB/c nu/nu mice by AIDS-KS cells. These findings represent a novel and potentially less toxic therapeutic approach for the treatment of AIDS-KS.
UR - http://www.scopus.com/inward/record.url?scp=0028151433&partnerID=8YFLogxK
U2 - 10.1084/jem.180.5.1949
DO - 10.1084/jem.180.5.1949
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C2 - 7525844
AN - SCOPUS:0028151433
SN - 0022-1007
VL - 180
SP - 1949
EP - 1954
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -
