Apolipoprotein E genotypes and age of onset in early‐onset familial Alzheimer's disease

Ephrat Levy‐Lahad, Amnon Lahad, Ellen M. Wijsman, Thomas D. Bird, Gerard D. Schellenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage to chromosome 14. The ϵ4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early‐onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE‐independent pathways.

Original languageAmerican English
Pages (from-to)678-680
Number of pages3
JournalAnnals of Neurology
Volume38
Issue number4
DOIs
StatePublished - Oct 1995
Externally publishedYes

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