TY - JOUR
T1 - Aptamer-Functionalized Micro- And Nanocarriers for Controlled Release
AU - Vazquez-Gonzalez, Margarita
AU - Willner, Itamar
N1 - Publisher Copyright:
©
PY - 2021/3/3
Y1 - 2021/3/3
N2 - Sequence-specific nucleic acids recognizing low-molecular-weight ligands or macromolecules (aptamers) have found growing interest for biomedical applications. The present review article summarizes recent applications of aptamers as stimuli-responsive gating units of drug (or dye)-loaded nano- or microcarriers for controlled and targeted drug release. In the presence of cellular biomarkers, the nano-/microcarriers are unlocked by forming aptamer-ligand complexes. Different aptamer-functinalized nano-/microcarriers are presented, including inorganic nanomaterials, metal-organic framework nanoparticles, and soft materials. The chemistries associated with the preparation of the carriers and the mechanisms to unlock the carriers are discussed. Stimuli-responsive gated drug-loaded micro-/nanocarriers hold great promise as functional sense-and-treat materials for the targeted and selective release of drugs.
AB - Sequence-specific nucleic acids recognizing low-molecular-weight ligands or macromolecules (aptamers) have found growing interest for biomedical applications. The present review article summarizes recent applications of aptamers as stimuli-responsive gating units of drug (or dye)-loaded nano- or microcarriers for controlled and targeted drug release. In the presence of cellular biomarkers, the nano-/microcarriers are unlocked by forming aptamer-ligand complexes. Different aptamer-functinalized nano-/microcarriers are presented, including inorganic nanomaterials, metal-organic framework nanoparticles, and soft materials. The chemistries associated with the preparation of the carriers and the mechanisms to unlock the carriers are discussed. Stimuli-responsive gated drug-loaded micro-/nanocarriers hold great promise as functional sense-and-treat materials for the targeted and selective release of drugs.
KW - carbon dots
KW - metal-organic framework particles
KW - microcapsules
KW - nanomaterials
KW - nanomedicine
KW - SiOnanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85099668177&partnerID=8YFLogxK
U2 - 10.1021/acsami.0c17121
DO - 10.1021/acsami.0c17121
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C2 - 33395247
AN - SCOPUS:85099668177
SN - 1944-8244
VL - 13
SP - 9520
EP - 9541
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 8
ER -