Abstract
Sequence-specific nucleic acids recognizing low-molecular-weight ligands or macromolecules (aptamers) have found growing interest for biomedical applications. The present review article summarizes recent applications of aptamers as stimuli-responsive gating units of drug (or dye)-loaded nano- or microcarriers for controlled and targeted drug release. In the presence of cellular biomarkers, the nano-/microcarriers are unlocked by forming aptamer-ligand complexes. Different aptamer-functinalized nano-/microcarriers are presented, including inorganic nanomaterials, metal-organic framework nanoparticles, and soft materials. The chemistries associated with the preparation of the carriers and the mechanisms to unlock the carriers are discussed. Stimuli-responsive gated drug-loaded micro-/nanocarriers hold great promise as functional sense-and-treat materials for the targeted and selective release of drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 9520-9541 |
| Number of pages | 22 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 13 |
| Issue number | 8 |
| DOIs | |
| State | Published - 3 Mar 2021 |
Bibliographical note
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Keywords
- SiOnanoparticles
- carbon dots
- metal-organic framework particles
- microcapsules
- nanomaterials
- nanomedicine