Neurospora crassa has been at the forefront of biological research from the early days of biochemical genetics to current progress being made in understanding gene and genetic network function. Here, we discuss recent developments in analysis of the fundamental form of fungal growth, development and proliferation - the hypha. Understanding the establishment and maintenance of polarity, hyphal elongation, septation, branching and differentiation are at the core of current research. The advances in the identification and functional dissection of regulatory as well as structural components of the hypha provide an expanding basis for elucidation of fundamental attributes of the fungal cell. The availability and continuous development of various molecular and microscopic tools, as utilized by an active and co-supportive research community, promises to yield additional important new discoveries on the biology of fungi.
Bibliographical noteFunding Information:
M. Freitag received grant support from the American Cancer Society ( RSG-08-030-01-CCG ). S. Free from the National Institutes of Health ( R01 GM078589 ). M. Riquelme from Consejo Nacional de Ciencia y Tecnología CONACyT ( U-45818Q , B0C022 ). O. Yarden from the Israel Science Foundation and the German Research Foundation ( SE1054/3-2 ). R. Mouriño from CONACyT ( SEP-2003-CO2-44724 and SEP-2007-CO2-82753 ), and UC-MEXUS/CONACyT 2007-2009 . C. Rasmussen from a postdoctoral fellowship from the American Cancer Society (# PF-08-280-01 ). S. Seiler from the German Research Foundation ( SE 1054/3-2 and SE1054/4-1 ). E. Castro from CONACyT ( CB-2006-1-61524 ). R. R. Lew from the Natural Sciences and Engineering Council of Canada . A. Fleißner from the German Research Foundation ( FL 706/1-1 ). We thank the Fungal Genetics Stock Center and the Neurospora Functional Genomics Program Project grant ( NIH P01GM068087 ) for materials and strains.
- Cell wall
- Hyphal growth