TY - JOUR
T1 - Are we ready to downregulate mast cells?
AU - Karra, Laila
AU - Berent-Maoz, Beata
AU - Ben-Zimra, Micha
AU - Levi-Schaffer, Francesca
N1 - Funding Information:
F Levi-Schaffer's research is supported by the Aimwell Charitable Trust (UK) and the Israeli Ministry of Health.
PY - 2009/12
Y1 - 2009/12
N2 - Downregulation of mast cells (MCs) function and/or survival is warranted in allergic inflammation (AI), mastocytosis/MC leukemias and in other inflammatory diseases in which MCs have a central role. Human MCs (hMCs) have been recently shown to express the death receptor (DR) TRAIL and the inhibitory receptors (IRs) CD300a and Siglec-8. TRAIL is the only known DR functional on hMCs, and interestingly its function is upregulated by IgE-dependent MC activation. The newly described IRs, CD300a and Siglec-8, potently downregulate MC activation and survival in vitro and inhibit different IgE-mediated responses in vivo. Therefore a selective targeting of TRAIL and of IRs on MC could be a novel immunopharmacological way to downregulate MC-associated diseases.
AB - Downregulation of mast cells (MCs) function and/or survival is warranted in allergic inflammation (AI), mastocytosis/MC leukemias and in other inflammatory diseases in which MCs have a central role. Human MCs (hMCs) have been recently shown to express the death receptor (DR) TRAIL and the inhibitory receptors (IRs) CD300a and Siglec-8. TRAIL is the only known DR functional on hMCs, and interestingly its function is upregulated by IgE-dependent MC activation. The newly described IRs, CD300a and Siglec-8, potently downregulate MC activation and survival in vitro and inhibit different IgE-mediated responses in vivo. Therefore a selective targeting of TRAIL and of IRs on MC could be a novel immunopharmacological way to downregulate MC-associated diseases.
UR - http://www.scopus.com/inward/record.url?scp=70449707323&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2009.09.010
DO - 10.1016/j.coi.2009.09.010
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C2 - 19837574
AN - SCOPUS:70449707323
SN - 0952-7915
VL - 21
SP - 708
EP - 714
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -