Are we ready to downregulate mast cells?

Laila Karra; Beata Berent-Maoz; Micha Ben-Zimra; Francesca Levi-Schaffer

doi:10.1016/j.coi.2009.09.010

Are we ready to downregulate mast cells?

Laila Karra^*, Beata Berent-Maoz, Micha Ben-Zimra, Francesca Levi-Schaffer

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Downregulation of mast cells (MCs) function and/or survival is warranted in allergic inflammation (AI), mastocytosis/MC leukemias and in other inflammatory diseases in which MCs have a central role. Human MCs (hMCs) have been recently shown to express the death receptor (DR) TRAIL and the inhibitory receptors (IRs) CD300a and Siglec-8. TRAIL is the only known DR functional on hMCs, and interestingly its function is upregulated by IgE-dependent MC activation. The newly described IRs, CD300a and Siglec-8, potently downregulate MC activation and survival in vitro and inhibit different IgE-mediated responses in vivo. Therefore a selective targeting of TRAIL and of IRs on MC could be a novel immunopharmacological way to downregulate MC-associated diseases.

Original language	English
Pages (from-to)	708-714
Number of pages	7
Journal	Current Opinion in Immunology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.coi.2009.09.010
State	Published - Dec 2009

Bibliographical note

Funding Information:
F Levi-Schaffer's research is supported by the Aimwell Charitable Trust (UK) and the Israeli Ministry of Health.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.coi.2009.09.010

Cite this

@article{bf790c25ef944a8b94a800c497965894,

title = "Are we ready to downregulate mast cells?",

abstract = "Downregulation of mast cells (MCs) function and/or survival is warranted in allergic inflammation (AI), mastocytosis/MC leukemias and in other inflammatory diseases in which MCs have a central role. Human MCs (hMCs) have been recently shown to express the death receptor (DR) TRAIL and the inhibitory receptors (IRs) CD300a and Siglec-8. TRAIL is the only known DR functional on hMCs, and interestingly its function is upregulated by IgE-dependent MC activation. The newly described IRs, CD300a and Siglec-8, potently downregulate MC activation and survival in vitro and inhibit different IgE-mediated responses in vivo. Therefore a selective targeting of TRAIL and of IRs on MC could be a novel immunopharmacological way to downregulate MC-associated diseases.",

author = "Laila Karra and Beata Berent-Maoz and Micha Ben-Zimra and Francesca Levi-Schaffer",

note = "Funding Information: F Levi-Schaffer's research is supported by the Aimwell Charitable Trust (UK) and the Israeli Ministry of Health.",

year = "2009",

month = dec,

doi = "10.1016/j.coi.2009.09.010",

language = "אנגלית",

volume = "21",

pages = "708--714",

journal = "Current Opinion in Immunology",

issn = "0952-7915",