ARREST OF DAUDI CELL GROWTH BY INACTIVE INFLUENZA VIRUS IN-VITRO.

We investigated the destructive capability of three influenza A strains, Victoria, PR8, and their recombinant X47, against the human lymphoma cell line Daudi. Both Victoria and X47 strains share the same envelope glycoproteins (H3N2), while PR8, the second parental strain of X47, differs in its envelope glycoproteins (HON1). The H3N2 strains and particularly the X47 recombinant were cytotoxic to Daudi cells while the HON1 strain was not. To reduce the virulence of the oncolytic viruses, we inactivated them either with heat or with formalin. Both treatments significantly reduced the infectivity of the viruses.