Sepphoris was a major urban centre in the Lower Galilee in the Roman and late antique periods. Architecturally, artistically, and culturally, it was not very different from the pagan cities of ancient Palestine, and its exposure to and assimilation of Graeco-Roman culture did not hinder Jewish life. This article compares the mosaics found in two public buildings constructed in early-5th c. C.E. Sepphoris, the Nile Festival Building and the synagogue, while arguing that these finds may imply close contact between artists working at different locations and for different communities within the city. This phenomenon demonstrates the city's distinct character in Late Antiquity and offers insight into the complexity of the cultural relationship between the Jews and other segments of that society.