Ascorbic acid in aqueous solution: Bathochromic shift in dilution and degradation

E. Touitou; D. Gilhar; F. Alhaique; A. Memoli; F. M. Riccieri; E. Santucci

doi:10.1016/0378-5173(92)90358-9

Ascorbic acid in aqueous solution: Bathochromic shift in dilution and degradation

E. Touitou^*, D. Gilhar, F. Alhaique, A. Memoli, F. M. Riccieri, E. Santucci

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Spectrophotometric and conductivity determinations were performed for aqueous solutions of ascorbic acid in the concentration range of 5.7 × 10^-5 to 10^- M. The results show a significant bathochromic shift of up to 30 nm of λ_max with a decrease in ascorbic acid concentration. The discrepancy between the absorbance values at λ_max and λ_fix was found to reach up to three absorbance units. These results have important implications for ascorbic acid stability tests and other systems in which ascorbic acid degradation occurs. When absorbance is directly read for ascorbic acid solutions of various concentrations, λ_max should be determined for each individual solution.

Original language	English
Pages (from-to)	85-87
Number of pages	3
Journal	International Journal of Pharmaceutics
Volume	78
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(92)90358-9
State	Published - 1 Jan 1992

Keywords

Ascorbic acid
Bathochromic shift
UV absorption
Vitamin C degradation

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title = "Ascorbic acid in aqueous solution: Bathochromic shift in dilution and degradation",

abstract = "Spectrophotometric and conductivity determinations were performed for aqueous solutions of ascorbic acid in the concentration range of 5.7 × 10-5 to 10- M. The results show a significant bathochromic shift of up to 30 nm of λmax with a decrease in ascorbic acid concentration. The discrepancy between the absorbance values at λmax and λfix was found to reach up to three absorbance units. These results have important implications for ascorbic acid stability tests and other systems in which ascorbic acid degradation occurs. When absorbance is directly read for ascorbic acid solutions of various concentrations, λmax should be determined for each individual solution.",

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T2 - Bathochromic shift in dilution and degradation

AU - Touitou, E.

AU - Gilhar, D.

AU - Alhaique, F.

AU - Memoli, A.

AU - Riccieri, F. M.

AU - Santucci, E.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Spectrophotometric and conductivity determinations were performed for aqueous solutions of ascorbic acid in the concentration range of 5.7 × 10-5 to 10- M. The results show a significant bathochromic shift of up to 30 nm of λmax with a decrease in ascorbic acid concentration. The discrepancy between the absorbance values at λmax and λfix was found to reach up to three absorbance units. These results have important implications for ascorbic acid stability tests and other systems in which ascorbic acid degradation occurs. When absorbance is directly read for ascorbic acid solutions of various concentrations, λmax should be determined for each individual solution.

AB - Spectrophotometric and conductivity determinations were performed for aqueous solutions of ascorbic acid in the concentration range of 5.7 × 10-5 to 10- M. The results show a significant bathochromic shift of up to 30 nm of λmax with a decrease in ascorbic acid concentration. The discrepancy between the absorbance values at λmax and λfix was found to reach up to three absorbance units. These results have important implications for ascorbic acid stability tests and other systems in which ascorbic acid degradation occurs. When absorbance is directly read for ascorbic acid solutions of various concentrations, λmax should be determined for each individual solution.

KW - Ascorbic acid

KW - Bathochromic shift

KW - UV absorption

KW - Vitamin C degradation

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Ascorbic acid in aqueous solution: Bathochromic shift in dilution and degradation

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Keywords

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