Assaying Interactions Between Neutrophils and Plasmodium falciparum-Infected Red Blood Cells

Tamir Zelter; Zvi Granot; Ron Dzikowski

doi:10.1007/978-1-0716-2189-9_47

Assaying Interactions Between Neutrophils and Plasmodium falciparum-Infected Red Blood Cells

Tamir Zelter, Zvi Granot, Ron Dzikowski^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the adaptive immune response in the course of malaria. However, in recent years there is mounting evidence for the role of the innate immune response to Plasmodium infections. In this context, very little is known on the protective role of neutrophils against blood-stage parasites and the mechanisms by which they recognize and eliminate infected red blood cells. Here we describe several useful methodologies that enable the study and quantification of the interactions between human neutrophils and P. falciparum-infected red blood cells.

Original language	American English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	629-639
Number of pages	11
DOIs	https://doi.org/10.1007/978-1-0716-2189-9_47
State	Published - 2022

Publication series

Name	Methods in Molecular Biology
Volume	2470
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Interaction
Neutrophils
Plasmodium
Red blood cells
Surface antigens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-0716-2189-9_47

Cite this

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abstract = "Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the adaptive immune response in the course of malaria. However, in recent years there is mounting evidence for the role of the innate immune response to Plasmodium infections. In this context, very little is known on the protective role of neutrophils against blood-stage parasites and the mechanisms by which they recognize and eliminate infected red blood cells. Here we describe several useful methodologies that enable the study and quantification of the interactions between human neutrophils and P. falciparum-infected red blood cells.",

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AU - Granot, Zvi

AU - Dzikowski, Ron

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N2 - Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the adaptive immune response in the course of malaria. However, in recent years there is mounting evidence for the role of the innate immune response to Plasmodium infections. In this context, very little is known on the protective role of neutrophils against blood-stage parasites and the mechanisms by which they recognize and eliminate infected red blood cells. Here we describe several useful methodologies that enable the study and quantification of the interactions between human neutrophils and P. falciparum-infected red blood cells.

AB - Plasmodium falciparum, which causes the deadliest form of human malaria, is able to evade antibody-mediated immune responses through switches in expression of surface antigens. Thus, over the years, the focus of most research has been on the role of the adaptive immune response in the course of malaria. However, in recent years there is mounting evidence for the role of the innate immune response to Plasmodium infections. In this context, very little is known on the protective role of neutrophils against blood-stage parasites and the mechanisms by which they recognize and eliminate infected red blood cells. Here we describe several useful methodologies that enable the study and quantification of the interactions between human neutrophils and P. falciparum-infected red blood cells.

KW - Interaction

KW - Neutrophils

KW - Plasmodium

KW - Red blood cells

KW - Surface antigens

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ER -

Assaying Interactions Between Neutrophils and Plasmodium falciparum-Infected Red Blood Cells

Abstract

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Bibliographical note

Keywords

UN SDGs

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