TY - JOUR
T1 - Assembly of a new growth cone after axotomy
T2 - The precursor to axon regeneration
AU - Bradke, Frank
AU - Fawcett, James W.
AU - Spira, Micha E.
PY - 2012/3
Y1 - 2012/3
N2 - The assembly of a new growth cone is a prerequisite for axon regeneration after injury. Creation of a new growth cone involves multiple processes, including calcium signalling, restructuring of the cytoskeleton, transport of materials, local translation of messenger RNAs and the insertion of new membrane and cell surface molecules. In axons that have an intrinsic ability to regenerate, these processes are executed in a timely fashion. However, in axons that lack regenerative capacity, such as those of the mammalian CNS, several of the steps that are required for regeneration fail, and these axons do not begin the growth process. Identification of the points of failure can suggest targets for promoting regeneration.
AB - The assembly of a new growth cone is a prerequisite for axon regeneration after injury. Creation of a new growth cone involves multiple processes, including calcium signalling, restructuring of the cytoskeleton, transport of materials, local translation of messenger RNAs and the insertion of new membrane and cell surface molecules. In axons that have an intrinsic ability to regenerate, these processes are executed in a timely fashion. However, in axons that lack regenerative capacity, such as those of the mammalian CNS, several of the steps that are required for regeneration fail, and these axons do not begin the growth process. Identification of the points of failure can suggest targets for promoting regeneration.
UR - http://www.scopus.com/inward/record.url?scp=84857371961&partnerID=8YFLogxK
U2 - 10.1038/nrn3176
DO - 10.1038/nrn3176
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C2 - 22334213
AN - SCOPUS:84857371961
SN - 1471-003X
VL - 13
SP - 183
EP - 193
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 3
ER -