Abstract
Developing novel neuroprobes that enable parallel multisite, long-term intracellular recording and stimulation of neurons in freely behaving animals is a neuroscientist’s dream. When fulfilled, it is expected to significantly enhance brain research at fundamental mechanistic levels including that of subthreshold signaling and computations. Here we assess the feasibility of merging the advantages of in vitro vertical nanopillar technologies that support intracellular recordings with contemporary concepts of in vivo extracellular field potential recordings to generate the dream neuroprobes that read the entire electrophysiological signaling repertoire.
| Original language | American English |
|---|---|
| Article number | 807797 |
| Journal | Frontiers in Neuroscience |
| Volume | 15 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Funding Information:The laboratory was supported by the Israel Science Foundation grant number 1808/19. Parts of the described studies were conducted at the Charles E. Smith and Joel Elkes Laboratory for Collaborative Research in Psychobiology. The perspective was based on an earlier research project supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01NS099687.
Funding Information:
The laboratory was supported by the Israel Science Foundation grant number 1808/19. Parts of the described studies were conducted at the Charles E. Smith and Joel Elkes Laboratory for
Publisher Copyright:
Copyright © 2022 Spira, Erez and Sharon.
Keywords
- immunohistology
- intracellular neuroimplant
- microelectrodes
- neural engineering
- neuro-electronics
- polyimide
- ultrastructure