Assessing the Feasibility of Developing in vivo Neuroprobes for Parallel Intracellular Recording and Stimulation: A Perspective

Micha E. Spira*, Hadas Erez, Aviv Sharon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Developing novel neuroprobes that enable parallel multisite, long-term intracellular recording and stimulation of neurons in freely behaving animals is a neuroscientist’s dream. When fulfilled, it is expected to significantly enhance brain research at fundamental mechanistic levels including that of subthreshold signaling and computations. Here we assess the feasibility of merging the advantages of in vitro vertical nanopillar technologies that support intracellular recordings with contemporary concepts of in vivo extracellular field potential recordings to generate the dream neuroprobes that read the entire electrophysiological signaling repertoire.

Original languageAmerican English
Article number807797
JournalFrontiers in Neuroscience
Volume15
DOIs
StatePublished - 25 Jan 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Spira, Erez and Sharon.

Keywords

  • immunohistology
  • intracellular neuroimplant
  • microelectrodes
  • neural engineering
  • neuro-electronics
  • polyimide
  • ultrastructure

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