Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

Peter W. Andrews; Uri Ben-David; Nissim Benvenisty; Peter Coffey; Kevin Eggan; Barbara B. Knowles; Andras Nagy; Martin Pera; Benjamin Reubinoff; Peter J. Rugg-Gunn; Glyn N. Stacey

doi:10.1016/j.stemcr.2017.05.029

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

Peter W. Andrews^*, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J. Rugg-Gunn, Glyn N. Stacey

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the safety of therapeutic applications of these cells can be assessed. A strong recommendation from the meeting was that an international advisory group should be set up to review the genetic and epigenetic changes observed in human pluripotent stem cell lines and establish a framework for evaluating the risks that they may pose for clinical use.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Stem Cell Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2017.05.029
State	Published - 11 Jul 2017

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Publisher Copyright:
© 2017

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Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

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