Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

Peter W. Andrews*, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J. Rugg-Gunn, Glyn N. Stacey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the safety of therapeutic applications of these cells can be assessed. A strong recommendation from the meeting was that an international advisory group should be set up to review the genetic and epigenetic changes observed in human pluripotent stem cell lines and establish a framework for evaluating the risks that they may pose for clinical use.

Original languageAmerican English
Pages (from-to)1-4
Number of pages4
JournalStem Cell Reports
Issue number1
StatePublished - 11 Jul 2017

Bibliographical note

Funding Information:
Funding for The International Stem Cell Initiative and for this meeting were provided by the International Stem Cell Forum ( Additional support for the meeting was provided by the Pluripotent Stem Cell Platform, a Hub funded by the UK Regenerative Medicine Platform, grant ref. MR/L012537/1, and also by Ajinomoto Inc., Stem Cell Technologies Inc. and Thermo Fisher Scientific. B.R. is founder, chief scientific officer, shareholder, and has interests in Cell Cure Neurosciences Ltd. The focus of the company is not related to the content of the manuscript. This report was prepared by the organizers and session chairs of the meeting.

Publisher Copyright:
© 2017


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