Assessment of the CoaguChek-XS portable prothrombin time point-of-care analyzer for horses

Noa Berlin, Efrat Kelmer, Gilad Segev, Itamar Aroch, Gal Kelmer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Coagulopathies in horses are common and potentially life-threatening. In equine field medicine, a portable point-of-care (POC) prothrombin time (PT) testing device could be useful to identify early changes in extrinsic clotting. The CoaguChek-XS (Roche Diagnostics) is a small, portable POC PT analyzer used in human medicine. Our preliminary study assessed the suitability of CoaguChek-XS for testing PT in horses and established the PT reference interval (PT RI) in healthy horses using this instrument. Blood samples collected from 102 healthy and ill horses were analyzed with the CoaguChek-XS and compared to a semi-automated coagulometric analyzer (SACA) as the gold standard. There was a significant positive correlation between the 2 measurement methods (r = 0.765, p < 0.01), and very good agreement, with 97% of the samples falling within limits of agreement. The mean CoaguChek-XS PT coefficient of variation was 0.8%, indicating high precision. With high precision and good agreement with the coagulometric PT, the CoaguChek-XS should be further validated for PT measurement in horses.

Original languageAmerican English
Pages (from-to)448-452
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume31
Issue number3
DOIs
StatePublished - 1 May 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).

Keywords

  • clotting
  • coagulation
  • equine
  • hemostasis
  • point-of-care testing

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